Brand Name: Priligy®
Dapoxetine, a new antidepressant, has been found to be safe and effective for the treatment of premature ejaculation, according to two major clinical trials. Dapoxetin is a short-acting selective serotonin reuptake inhibitor (SSRI).
* Note: All prices in Bitcoin (BTC). The Bitcoin exchange rate is calculated using an average price from several leading exchange providers. Local currency conversions are provided for your convenience.
† The pharmacy dispenses the product displayed. In the case of a product shortage, the pharmacy may substitute with an alternative generic.
Other Known Brand Names for Priligy
- Appynite (Intas Pharmaceuticals Pvt. Ltd.)
- Dapox (Ranbaxy Laboratories Ltd.)
- Duralast (Sun Pharmaceutical Industries Ltd.)
- Duratia (Centurion Laboratories)
- Everlast (SAVA Healthcare Limited)
- Justinex (Emcure Pharmaceuticals Ltd.)
- Kutub (Hetero Healthcare Ltd.)
- Poxet (Sunrise Remedies)
- Priligy (Johnson & Johnson)
- Prilyxet (Sun Pharmaceutical Industries Ltd.)
- Sustinex (Emcure Pharmaceuticals Ltd.)
- Vriligy (Centurion Laboratories)
- Xydap (Cipla Limited)
The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal re-uptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre- and postsynaptic receptors. Human ejaculation is primarily mediated by the sympathetic nervous system. The ejaculatory pathway originates from a spinal reflex center, mediated by the brainstem, which is influenced initially by a number of nuclei in the brain (medial preoptic and paraventricular nuclei). In the rat, dapoxetine inhibits the ejaculatory expulsion reflex by acting at a supraspinal level with the lateral paragigantocellular nucleus (LPGi) as a necessary brain structure for the effect. Postganglionic sympathetic fibers that innervate the seminal vesicles, vas deferens, prostate, bulbourethral muscles, and bladder neck cause them to contract in a coordinated fashion to achieve ejaculation. Dapoxetine modulates this ejaculatory reflex in rats, causing an increase in pudendal motoneuron reflex discharge (PMRD) latency and a reduction in PMRD duration.
The recommended starting dose for all patients is 30 mg, taken as needed approximately 1-3 hrs prior to sexual activity. If the effect of 30 mg is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg. The maximum recommended dosing frequency is once every 24 hrs. If the patient has had orthostatic reactions on the starting dose, no dose escalation to 60 mg should be performed.
Disclaimer: Information and data on Dapoxetine (generic Priligy®) found on this website is for informational purposes only. This information does not constitute legal advice and it is recommended to first check all information with your medical practitioner.