- capsule EC
Brand Name: Cymbalta®
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may become unbalanced and cause depression.
Duloxetine is used to treat major depressive disorder and general anxiety disorder.
Duloxetine is also used to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).
Duloxetine is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy).
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Other Known Brand Names for Cymbalta
- Ambidext (Crescent Pharmaceuticals)
- Anxiostar (SAVA Healthcare Limited)
- Cendu (USV Limited)
- Cymbalta (Eli Lilly)
- Delok (Abbott Piramal India Ltd.)
- Deneuron (Otsira Genetica (div. of Aristo Pharma))
- Detine (Zephyr Unique Pharmaceutical Labs)
- Dufez (Akums Drugs & Pharmaceutical Ltd)
- Dulane (Sun Pharmaceutical Industries Ltd.)
- Dulot (Lupin Limited)
- Dulotin (Icon Pharma)
- Duloxee (Talent India)
- Duloxyl (Cipla Limited)
- Dumore (Lupin Limited)
- Dupact (Wockhardt Ltd.)
- Durapain (Abbott Piramal India Ltd.)
- Dureep (Pentacare (Alkem))
- Dutin (Ranbaxy Laboratories Ltd.)
- Duvanta (Intas Pharmaceuticals Pvt. Ltd.)
- Duxet (Unichem Laboratories Ltd.)
- Duzac (Cipla Limited)
- Duzela (Sun Pharmaceutical Industries Ltd.)
- Neuroxetin (Aristo Pharmaceuticals Ltd.)
- Symbal (Torrent Pharmaceuticals Ltd.)
- Sympta (IPCA Laboratories Ltd.)
- Ulozet (Sun Pharmaceutical Industries Ltd.)
- Yentreve (Eli Lilly)
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Try to take the medicine at the same time each day. Follow the directions on your prescription label.
Do not crush, chew, break, or open an extended-release capsule. Swallow it whole.
It may take 4 weeks or longer before your symptoms improve. Keep using the medication as directed. Do not stop using duloxetine without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.
Store at room temperature away from moisture and heat.
Usual Adult Dose for Pain
For use in the management of neuropathic pain associated with diabetic peripheral neuropathy and for the management of chronic musculoskeletal pain in patients with chronic low back pain and chronic pain due to osteoarthritis:
Usual Dose: 60 mg once a day without regard to meals.
For patients in whom tolerability is a concern, a lower starting dose may be considered.
Although a 120 mg per day dose was shown to be safe and effective, there is no evidence that doses higher than 60 mg have any additional benefit. Furthermore, the higher dose has been clearly less well tolerated.
Efficacy beyond 12 weeks has not been systematically studied in placebo-controlled studies, but a one year open label safety study has been conducted.
Usual Adult Dose for Depression
Initial Dose: 40 mg per day (administered as 20 mg twice daily) to 60 mg per day (given either once a day or as 30 mg twice daily) without regard to meals.
Usual Adult Dose for Anxiety
Initial dose: 60 mg orally once a day If necessary, dosage may be increased in increments of no more than 30 mg per day Maximum dose: 120 mg per day For patients in whom tolerability is a concern, a lower an initial dose of 30 mg orally once a day may be considered. Following one week of therapy, the dose may be increased to 60 mg orally once a day in this patient population. Although a 120 mg per day dose was shown to be safe and effective, there is no evidence that doses higher than 60 mg have any additional benefit.
It is generally agreed that episodes of generalized anxiety disorder require several months or longer of sustained pharmacological therapy. Maintenance of efficacy in generalized anxiety disorder has been demonstrated with duloxetine as monotherapy. Duloxetine should be administered in a dose range of 60 to 120 mg once daily. Patients should be periodically reassessed to determine the continued need for maintenance treatment and the appropriate dose for such treatment.
Usual Adult Dose for Fibromyalgia
Initial Dose: 30 mg once a day without regard to meals for one week.
Usual Dose: 60 mg once a day without regard to meals.
Treatment should begin at 30 mg once daily for 1 week, to allow patients to adjust to the medication before increasing to 60 mg once daily. Some patients may respond to the starting dose. There is no evidence that doses greater than 60 mg/day confer additional benefit, even in patients who do not respond to a 60 mg dose, and higher doses are associated with a higher rate of adverse reactions.
Fibromyalgia is recognized as a chronic condition. The efficacy of duloxetine in the management of fibromyalgia has been demonstrated in placebo-controlled studies up to three months. The efficacy of duloxetine was not demonstrated in longer studies; however, continued treatment should be based on individual patient response.
Disclaimer: Information and data on Duloxetine (generic Cymbalta®) found on this website is for informational purposes only. This information does not constitute legal advice and it is recommended to first check all information with your medical practitioner.